Objective:
To evaluate the efficacy of cyclosporine solution 0.09% in patients with dry eye uncontrolled on cyclosporine emulsion 0.05%.
Key Findings:
- Statistically significant decrease in total corneal fluorescein staining and mSANDE scores at weeks 4, 8, and 12.
- Improvements were consistent across age and sex subgroups.
- Cyclosporine 0.09% was safe and well tolerated.
Interpretation:
Ophthalmologists should consider switching patients inadequately controlled on cyclosporine 0.05% to cyclosporine 0.09% based on significant improvements observed.
Limitations:
- Single-arm study design may limit generalizability.
- No control group for comparison.
Conclusion:
The study indicates that cyclosporine solution 0.09% is effective for patients previously uncontrolled on cyclosporine emulsion 0.05%, with early improvements noted.
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